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Pao YP, (Yu CC), Lin YZ, Chatterjee S, Saha S, Tiwari N, Huang YT, Wu CC*, Choi D*, Lin ZH* (2021-07) Nano Energy 85, 106008 “Carbohydrate-Protein Interactions Studied by Solid-Liquid Contact Electrification and its Use for Label-Free Bacterial Detection.”.
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Ooi KE, Zhang XW, Kuo CY, Liu YJ, (Yu CC)* (2022-05) Frontiers in Chemistry 10, 905105 “Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose.”.Specific systems of interest are: 1) Discovering new enzymes as biocatalysts for human milk-type glycan synthesis 2) Chemoenzymatic synthesis of the human milk oligosaccharide library and 3) The function of human milk oligosaccharides in human gut microbiota and to investigate their roles in preventing the pathogenic infections. The major area of focus is human milk glycans. My underlying research philosophy is to work on problems in which developing methods for preparing novel, structurally-interesting glycans leads to tools for studying vital biological problems. The long-term goals of our research program are to develop state-of-the-art methods for assembling complex, biologically-relevant carbohydrates (glycans) that can be used to probe their function in nature. Students and postdoctoral fellows in the group use synthetic chemistry and enzymatic strategy to prepare compounds with interesting biological activities and then have the opportunity to use them in either biochemical or conformational studies. Our research program is focused in the areas of biosynthetic chemistry (with a particular emphasis in enzymatic carbohydrate synthesis), the structure determination/analysis of oligosaccharides and the discovery of novel carbohydrate-active enzymes that can be used in complex oligosaccharide synthesis. Proteomics Mass Spectrometry Common Facility.Mammalian cell-based recombinant protein expression.Personal Information Protection Act Disclosure.
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